At the Hawthorns West Bromwich Albion take on Southampton on the opening day, kick off begins at 10:00am ET.
The Baggies are looking to build on their impressive 2012-13 season, when they finished eighth in the Premier League.
Steve Clarke starts with new signing Nicholas Anelka, as the veteran French striker returns to the Premier League.
While Southampton start with three teenagers in their lineup, with Callum Chambers, Luke Shaw and James Ward-Prowse all getting the nod. New signings Dejan Lovren and Victor Wanyama also start for the Saints.
An open game is expected in the Midlands, watch it live here on NBC Sports Live Extra.
And discuss the talking points of the game as it happens, right here on ProSoccerTalk.
West Brom: Foster; Jones, McAuley, Olsson (c), Ridgewell; Morrison, Mulumbu, Yacob, Dorrans; Anelka, Long. Subs: Myhill, Vydra, Rosenberg, Brunt, Dawson, Berahino, Popov.
Southampton: Boruc, Chambers, Fonte, Lovren, Shaw, Wanyama, Schneiderlin, Ward-Prowse, Lallana (c), Rodriguez, Lambert. Subs: K. Davis (GK), Clyne, S. Davis, Ramírez, Cork, Mayuka, Hooiveld.