After a two-match Tuesday appetizer, the Premier League quadruples the action with eight Wednesday matches.
Bournemouth held off Leicester 1-0 down south, while Everton got a pair of goals from backs to end Arsenal’s 14-match unbeaten Premier League run.
Wednesday’s slate see most of the Premier League’s perceived big boys viewed as favorites, even with three of five active Top Six teams on the road.
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Chelsea has a chance to open up a six-point lead on second-place Arsenal when it visits last-place Sunderland, while Liverpool can climb level with the Gunners with a win at Middlesbrough.
Also on the road is Manchester United, currently six points back of the Top Four. Jose Mourinho leads the Red Devils into Selhurst Park to meet high-flying but goal-leaking Crystal Palace.
Manchester City and Tottenham Hotspur hope that home-cooking can help them close in on the league leaders. City has dropped two-straight PL contests to sink 7 points back of Chelsea, and will hope inconsistent Watford brings one of its lesser performances to the Etihad Stadium.
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Burnt by a loss at Old Trafford this weekend, Spurs host a Hull side who showed a spark in a 3-3 home draw with Palace.
Premier League Wednesday slate
Middlesbrough vs. Liverpool — 2:45 p.m. EDT
West Ham vs. Burnley — 2:45 p.m. EDT
Sunderland vs. Chelsea — 2:45 p.m. EDT
Manchester City vs. Watford — 3 p.m. EDT
Stoke City vs. Southampton — 3 p.m. EDT
Tottenham Hotspur vs. Hull City — 3 p.m. EDT
West Bromwich Albion vs. Swansea City — 3 p.m. EDT
Crystal Palace vs. Manchester United — 3 p.m. EDT