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SOUTHAMPTON, ENGLAND - DECEMBER 19:  Harry Kane of Tottenham Hotspur is chased Jordy Clasie (4) and Victor Wanyama of Southampton (12) during the Barclays Premier League match between Southampton and Tottenham Hotspur at St Mary's Stadium on December 19, 2015 in Southampton, England.  (Photo by Charlie Crowhurst/Getty Images)
Photo by Charlie Crowhurst/Getty Images

Watch Live: Tottenham Hotspur vs. Southampton (Lineups, Live Stream)

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Spurs look to put a stranglehold on the Premier League’s second place with a win over visiting Southampton on Sunday (Watch live, 8:30 a.m. ET on NBCSN and online via Live Extra).

Tottenham sacrificed its slim chance at the PL title during a card- and discipline-filled draw with Chelsea on Monday, but still hold a three-point advantage on Arsenal. Spurs also hold a comfortable 14-goal advantage in differential on their North London Derbymates.

[ MORE: Premier League’s Saturday roundup ]

Spurs will be without suspended Mousa Dembele and Dele Alli.

As for Saints, a win keeps them in the discussion for sixth place. Southampton is two points shy of West Ham, who has two more matches to play, and two ahead of Liverpool. The Reds have three matches left.

LINEUPS

Spurs: Lloris, Walker, Alderweireld, Vertonghen, Rose; Dier, Mason; Lamela, Eriksen, Son; Kane. Subs: Vorm, Davies, Wimmer, Carroll, Chadli, Winks, Clinton.

Saints: Forster; Bertrand, Fonte, Van Dijk, Martina, S. Davis, Clasie, Wanyama, Tadic, Mane, Long. Subs: Stekelenburg, Cedric, Yoshida, Romeu, Ward-Prowse, Pelle, Austin.

Watch Live: Tottenham Hotspur vs. Manchester United (Lineups and Live Stream)

LONDON, ENGLAND - APRIL 10: A groundsman marks out the pitch prior to the Barclays Premier League match between Tottenham Hotspur and Manchester United at White Hart Lane on April 10, 2016 in London, England.  (Photo by Clive Rose/Getty Images)
Photo by Clive Rose/Getty Images
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United is late, and the game has been delayed at least 15 minutes, but Spurs and the Red Devils will tangle soon (Watch live on NBCSN and online via Live Extra).

Jan Vertonghen returns for Tottenham Hotspur as they look to keep up their long-odds title fight with a win over Manchester United at White Hart Lane on Sunday.

The youth movement is still quite real for Louis Van Gaal‘s Red Devils, with Timothy Fosu-Mensah, Jesse Lingard, Anthony Martial and Marcus Rashford all in the Starting XI.

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LINEUPS

Tottenham Hotspur: Lloris, Walker, Alderweireld, Vertonghen, Rose; Dier, Dembele; Lamela, Eriksen, Alli; Kane. Subs: Vorm, Son, Mason, Trippier, Chadli, Wimmer, Carroll.

Manchester United: De Gea, Fosu-Mensah, Smalling, Blind, Rojo, Schneiderlin, Carrick, Mata, Lingard, Martial, Rashford. Subs: Romero, Darmian, Valencia, Young, Fellaini, Herrera, Memphis.

Watch Live: Swansea City vs. Aston Villa (Lineups and Live Stream)

BIRMINGHAM, ENGLAND - OCTOBER 24: Jordan Ayew of Aston Villa and Jefferson Montero of Swansea City compete for the ball during the Barclays Premier League match between Aston Villa and Swansea City at Villa Park on October 24, 2015 in Birmingham, England.  (Photo by Michael Regan/Getty Images)
Photo by Michael Regan/Getty Images
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Spring ahead for a 1:30 p.m. ET match between two relegation strugglers at the Liberty Stadium on NBCSN this fine Saturday.

[ LIVE: Stream every PL game via Live Extra ]

All but relegated, Aston Villa has a chance to keep Swansea City’s fortunes on edge when the pair tangle in Wales.

While Andre Ayew’s injury keeps us from an Ayew Derby, Jordan Ayew will start for last-place Villa.

LINEUPS

Swansea City: Fabianski, Rangel, Fernandez, Williams (C), Kingsley, Cork, Ki, Fer, Barrow, Sigurdsson, Gomis. Subs: Nordfeldt, Naughton, Amat, Britton, Montero, Routledge, Paloschi.

Aston Villa: Guzan; Cissokho, Lescott, Clark, Hutton; Gana, Westwood; Veretout, Gil, Ayew; Gestede. Subs: Okore, Bacuna, Sinclair, Agbonlahor, Sanchez, Green, Bunn

Watch Live, Stream — Norwich City vs. Manchester City (Lineups)

during the Emirates FA Cup third round match between Norwich City and Manchester City at Carrow Road on January 9, 2016 in Norwich, England.
Photo by Michael Regan/Getty Images
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Desperation is the name of the game as relegation-threatened Norwich City hosts Champions League hopeful Manchester City at Carrow Road on Saturday (Watch live, 7:45 a.m. ET on NBCSN and online via Live Extra).

Man City is 10 points back of first place with a match-in-hand on the field, but just a point ahead of fifth-place West Ham and three in front of sixth-place Manchester United.

[ JPW: Premier League predictions for Week 30 ]

Norwich is tied on points for 17th place for three clubs but is headed down on goal differential as it stands.

On a weekend where just half of the PL clubs play league games, the Canaries will hope to put pressure on idle Sunderland and a Newcastle side which visits King Power Stadium on Monday.

LINEUPS

Norwich City: Ruddy; Martin (c), Bennett, Klose, Olsson; Howson, O’Neil; Redmond, Hoolahan, Jarvis; Bamford. Subs: Rudd (GK), Bassong, Mbokani, Jerome, Dorrans, Mulumbu, Pinto.

Manchester City: Hart, Sagna, Kompany, Otamendi, Clichy, Fernando, Fernandinho, Navas, Silva, Aguero, Bony. Subs: Caballero, Demichelis, Kolarov, Zabaleta, M.Garcia,  Sterling, Iheanacho.

Watch Live, Stream: Sunderland vs. Everton in U21 Premier League

LIVERPOOL, ENGLAND - DECEMBER 14:  Cameron Carter-Vickers of Spurs U21s and Sam Byrne of Everton U21s battle for the ball during the Barclays U21 Premier League match between Everton U21 and Tottenham Hotspur U21 at Southport FC on December 14, 2015 in Southport, England.  (Photo by Alex Livesey/Getty Images)
Photo by Alex Livesey/Getty Images
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The Stadium of Light is the venue for a U21 Premier League encounter between Sunderland and Everton on Monday (Watch live 3 p.m. ET on NBCSN and online via Live Extra).

Sunderland sits in second place, though the Black Cats have played in three more matches than fifth place Everton. The Toffees have 23 points, 12 back of their hosts.

[ PL PLAYBACK — Leicester strengthens; McClaren, Martinez in trouble ]

The Black Cats lost to Leicester City in their last match. Here’s coach Andy Welsh:

“Against Everton we have got to get a response, we have got to take our chances and hopefully we can get a better result against Everton.

“All season we have had a no fear factor and against Everton we have got to work hard to make sure we do exactly the same again.”

Sunderland is without USMNT hopeful Lynden Gooch, who is on loan at Doncaster Rovers.