A top of the table clash takes place at the Emirates Stadium, as Arsenal host Southampton (watch live on NBCSN and online via NBC Sports Live Extra) when first play third.
The Gunners and Saints have both been flying high this season and whoever wins this clash could be top of the table on Saturday evening.
Arsene Wenger has decided to recall Per Mertesacker after he missed the defeat to Arsenal last week. The Gunners are full strength going forward with Mesut Ozil and Santi Cazorla supporting Olivier Giroud.
As for Southampton, Argentine manager Mauricio Pochettino has made just one change from the team that beat Hull City 4-1 last time out as Jos Hooiveld replaces the injured Dejan Lovren at center back.
Can the Saints upset Arsenal and jump ahead of them in the league?
Arsenal: Szczesny, Sagna, Koscielny, Mertesacker, Gibbs, Arteta, Ramsey, Wilshere, Ozil, Cazorla, Giroud
Southampton: Boruc, Clyne, Fonte, Hooiveld, Shaw, Wanyama, Schneiderlin, Ward-Prowse, Lallana, Rodriguez, Lambert.