One of the season’s biggest fixtures comes our way at 11:00am ET as David Moyes has a chance at Stamford Bridge to prove his side belongs with the big guns.
You can watch the big game live on NBCSN or live online at NBC Sports Live Extra.
The visitors will have things made much more difficult for them with both Wayne Rooney and Robin van Persie out injured.
That means Danny Welbeck continues to serve as the main man up front, and Belgian youngster Adnan Januzaj slots in just behind the striker.
It will be an uphill battle for David Moyes. Not only has he never defeated Jose Mourinho head-to-head, but the Chelsea manager has never lost a Premier League match at Stamford Bridge.
He will be boosted by the return of midfield talisman Frank Lampard, back from a calf injury and on the bench. Branislav Ivanovic also returns from a knee injury and is a surprise start for the home side.
Mourinho has chosen Samuel Eto’o up front in the never-ending carousel of strikers at Stamford Bridge. Fernando Torres has seen an uptick in form, but apparently that wasn’t enough to get him the start.
New Chelsea signing Nemanja Matic is in the squad on the bench.
Chelsea – Cech; Ivanovic, Cahill, Terry, Azpilicueta; Ramires, Luiz; Willian, Oscar, Hazard; Eto’o.
Bench – Schwarzer, Cole, Mikel, Matic, Lampard, Mata, Torres.
Manchester United – De Gea; Rafael, Evans, Vidic, Evra; Valencia, Carrick, Jones, Young, Januzaj; Welbeck.
Bench – Lindegaard, Giggs, Smalling, Hernandez, Cleverley, Fletcher, Kagawa.