With Liverpool picking apart their arch rivals earlier this morning, the North London derby is next up on NBCSN and live online at NBC Sports Live Extra at 12:00pm ET.
A pair of teams with high aspirations but a dip in form could see one of them turn their season around against a hated opponent.
Spurs have dropped two of their last three Premier League fixtures, and they fell 3-1 midweek to Benfica in the Europa League.
Meanwhile, Arsenal have fallen back to fourth in the league table, seven points back of Chelsea in the lead.
Tim Sherwood has been very outspoken in the last week about his team’s apparent lack of heart, and he’s thin all over the pitch.
A pair of defenders in Kyle Walker and Michael Dawson miss out with injury, bringing in Kyle Naughton and Younes Kaboul to deputize.
Moussa Dembele also fails to prove fit in time, while Etienne Capoue, Erik Lamela and Vlad Chiriches are all out as well.
However, the biggest-name injury miss falls with the Gunners, as Mesut Ozil begins his month-long absence with a hamstring tear.
Jack Wilshere, Aaron Ramsey, and Theo Walcott are all long-term misses as well, but Kieran Gibbs does pass a fitness test to feature despite a knock.
Tottenham – Lloris; Naughton, Kaboul, Vertonghen, Rose; Sandro; Townsend, Bentaleb, Eriksen, Chadli; Adebayor.
Bench – Friedel, Walker, Lennon, Paulinho, Sigurdsson, Kane, Soldado.
Arsenal – Szczesny; Sagna, Koscielny, Mertesacker, Gibbs; Arteta, Rosicky, Oxlade-Chamberlain, Podolski, Cazorla; Giroud.
Bench – Fabianski, Monreal, Vermaelen, Jenkinson, Flamini, Gnabry, Sanogo.