Tottenham has the chance to return to the top four as they travel to the Stadium of light at 10am ET live online on NBC Sports Live Extra.
Spurs have six points in their first three matches and have looked bright overall, with a revitalized Christian Eriksen continuing to lead the way.
Eriksen starts with Erik Lamela and Nasir Chadli in the attacking midfield, with Moussa Dembele getting a spot start behind them alongside Etiene Capoue. Paulinho continues to miss out with new boss Mauricio Pochettino choosing against utilizing the Brazilian.
There are some injury concerns for Spurs as Roberto Soldado, Jan Vertonghen, and Kyle Walker all miss out, while Naleb Bentaleb was only able to return late Thursday from international duty which means he is not in the squad.
Meanwhile, Gus Poyet faces his old club, where he used to ply his trade as a player and also spent time as an assistant manager. He has new signings Sebastian Coates and Ricky Alvarez at his disposal, and has chosen to start the latter, while Coates will have to work to make the matchday squad.
There are no injury woes for the Black Cats, and they have Conor Wickham starting up front with the support of the new Argentine behind him.
Sunderland has failed to win in any of their last eight Premier League matches against Tottenham.
Sunderland: Mannone; Vergini, van Aanholt, Brown, O’Shea; Cattermole, Larsson, Rodwell, Johnson, Alvarez; Wickham
Bench: Pantilimon, Jones, Bridcutt, Gomez, Giaccherini, Buckley, Altidore.
Tottenham: Lloris; Dier, Kaboul, Chiriches, Rose; Dembele, Capoue; Lamela, Eriksen, Chadli; Adebayor.
Bench: Vorm, Fazio, Naughton, Lennon, Stambouli, Townsend, Kane.