Manchester City looks to cement its place behind the likely champions Chelsea as they travel to London to take on Tottenham Hotspur at White Hart Lane live on NBCSN at 11am ET or live online at NBC Sports Live Extra.
The visitors are struggling with injuries to a number of important players, but should they pull out a win they could go four points clear of Arsenal in second place, although well behind Chelsea who are all but secure at the top.
Most notably, Yaya Toure and Vincent Kompany are both missing from the Manchester City lineup, with the former picking up a hamstring injury against Aston Villa that could keep him out the rest of the season, although he surprisingly made the trip to London. Kompany will miss his third straight match due to an adductor tear.
Those injuries mean Eliaquim Mangala will get the start along the back line, while Fernandinho and Fernando pair up in midfield along with James Milner and Frank Lampard. Sergio Aguero starts up front, with both Edin Dzeko and Wilfried Bony on the bench. Samir Nasri comes back from injury to make the bench.
For Tottenham, left-back Ben Davies has been shut down for the season with a dislocated shoulder, but Danny Rose does prove fit to play in his place. Those are the only injury issues for the home side, as Harry Kane again romps up front while supported by Nacer Chadli, Christian Eriksen, and Erik Lamela.
Tottenham: Lloris; Dier, Fazio, Vertonghen, Rose; Bentaleb, Mason; Chadli, Eriksen, Lamela; Kane
Bench: Vorm, Chiriches, Yedlin, Paulinho, Stambouli, Adebayor, Soldado
Manchester City: Hart, Zabaleta, Demichelis, Mangala, Kolarov, Fernandinho, Fernando, Milner, Lampard, Silva, Aguero
Bench: Caballero, Sagna, Boyata, Clichy, Nasri, Dzeko, Bony