Jurgen Klopp takes charge of his first Premier League fixture at Anfield as Liverpool hosts Southampton live on NBC at 12:15 p.m. ET or live online at NBC Sports Live Extra.
Liverpool has won three straight over Southampton, but the Saints come to Merseyside on a three-match unbeaten streak, with a pair of wins over that span.
Christian Benteke and Roberto Firmino are set to return after a month-long absence, as both came on as substitutes in the midweek Europa League draw with Rubin Kazan. Both start on the bench, and with Daniel Sturridge out with a knee injury, Divock Origi starts up front for the Reds
For Southampton, goalkeeper Maarten Stekelenburg is available despite a back injury, and he starts between the sticks. Jay Rodriguez misses out due to a foot injury. Graziano Pelle starts up front for the Saints, but only three of his 17 career league goals have come on the road.
Liverpool: Mignolet, Clyne, Skrtel, Sakho, Moreno, Lucas, Can, Milner, Coutinho, Lallana, Origi
Subs: Bogdan, Toure, Benteke, Firmino, Allen, Ibe, Randall.
Southampton: Stekelenburg, Cédric, Fonte, van Dijk, Bertrand, Wanyama, Clasie, S. Davis, Mané, Tadić, Pellè.
Subs: K. Davis, Yoshida, Romeu, Ward-Prowse, Ramírez, Juanmi, Caulker.