Spurs are currently nine games unbeaten (the longest unbeaten streak in the Premier League) and are the overwhelming favorites against an Aston Villa side who sit bottom of the table.
Villa did appoint Frenchman Remi Garde as their new manager on Monday but he has a huge task on his hands to turnaround things at Villa Park with former boss Tim Sherwood fired following a dreadful start to the season which saw the Midlands club lose eight of their opening 10 matches.
In team news Spurs start with Dele Alli, Eric Dier and Mousa Dembele in midfield, while caretaker boss Kevin MacDonald starts Jack Grealish and Scott Sinclair with Gabriel Agbonlahor in an attacking lineup.
Tottenham Hotspur: Lloris, Walker, Alderweireld, Vertonghen, Rose; Alli, Dier, Dembele, Eriksen, Lamela; Kane. Subs: Vorm, Davies, Fazio, Trippier, Mason, Onomah, Townsend
Aston Villa: Guzan; Hutton, Clark, Lescott, Richardson; Sanchez, Westwood, Bacuna; Grealish, Sinclair, Agbonlahor. Subs: Bunn, Veretout, Ayew, Amavi, Gil, Crespo, Gestede