With a draw against Bournemouth on Boxing Day, the Eagles now sit fifth on the Premier League table.
Both Bolasie and Wickham did not feature in that draw, with Bolasie hurting his leg in training and Wickham picking up a calf injury after scoring at Stoke last weekend.
[ MORE: Boxing Day roundup ]
If the duo is out for a month, they would miss an important six-match stretch for Palace. During that time, the Eagles play Chelsea, Manchester City and Tottenham. They also play Southampton in the third round of the FA Cup on January 9.
Bolasie has featured in 16 of Palace’s 18 matches this season, and is one of the key players in Alan Pardew‘s side. The Congolese winger is extremely speedy and shifty, and can be one of the hardest players to mark in the Premier League when he is on top of his game.
Wickham has only scored one goal for Palace since moving to Selhurst Park from Sunderland this summer, and missed more than two months earlier this season with a rib injury. When fit, the 22-year-old has been Alan Pardew’s first-choice striker.