Injury-depleted Manchester United hopes Europa hero Marcus Rashford and Jesse Lingard can help them upset visiting Arsenal on Sunday (Watch live, 9:05 a.m. ET on NBCSN and online via Live Extra).
United also starts Guillermo Varela and Marcos Rojo at fullback against dangerous Arsenal.
The Gunners will have Per Mertesacker and Olivier Giroud on the bench as they look to keep pace with table-topping Leicester City, which beat Norwich City 1-0 on Saturday.
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Manchester United: De Gea; Varela, Carrick, Blind, Rojo; Schneiderlin, Herrera; Lingard, Mata, Memphis; Rashford. Subs: Romero, McNair, Riley, Fosu-Mensah, Weir, Januzaj, A.Pereira.
Arsenal: Cech; Bellerin, Gabriel, Koscielny, Monreal; Coquelin, Ramsey, Walcott, Ozil, Alexis, Welbeck. Subs: Ospina, Mertesacker, Gibbs, Elneny, Campbell, Iwobi, Giroud.