In a week which has seen the Gunners knocked out of both the FA Cup and UEFA Champions League, Wenger knows his side must beat Everton to keep their slim chances of winning the Premier League alive.
Arsenal has won one of its last eight games in all competitions.
As for Everton, Roberto Martinez has also been under pressure despite leading the Toffees to the FA Cup semifinals. A defeat coupled with other results going against them could see Everton fall to 14th place in the table.
Everton: Joel, Baines, Funes Mori, Jagielka, Coleman; McCarthy, Besic; Cleverley, Lennon, Barkley; Lukaku. Subs: Howard, Stones, Kone, Niasse, Deulofeu, Osman, Galloway
Arsenal: Ospina, Bellerin, Koscielny, Gabriel, Monreal; Coquelin, Elneny; Iwobi, Ozil, Sanchez; Welbeck. Subs: Macey, Gibbs Mertesacker, Walcott, Giroud, Campbell, Chambers