West Ham dominated the game but not the score line against Romanian side Astra Giurgiu, who advanced to the UEFA Europa League group stage with a 1-0 win at London Stadium on Thursday.
Well-traveled French midfielder Filipe Teixeira did the damage for Astra Giurgiu, as the former West Brom and Barnsley man scored in the 45th minute to give the visitors a 2-1 lead on aggregate after the sides went 1-1 in Romania last week.
The Irons carried possession and a wealth of shots, but couldn’t find their way past Romanian international goalkeeper Silviu Lung, Jr.
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Sassuolo star Domenico Berardi scored in a 1-1 draw with Red Star Belgrade, completing a 4-1 score line.
Elsewhere, a hat trick from Slovan Liberec’s Jan Sykora led the Czech side to a 3-0 second leg win, and 4-0 aggregate defeat of Cypriot side AEK Larnaca.
Gent got a pair of goals from giant Malian striker Kalifa Coulibaly as the Belgians completed a 6-1 aggregate win over Shkendija.
West Ham United 0-1 (agg. 1-2) Astra Giurgiu
Astana 2-2 (agg. 4-2) BATE Borisov
Arouca 1-2 (agg. 1-3) Olympiacos
Midtjylland 0-3 (agg. 0-4) Osmanlispor
Trencin 2-0 (agg. 0-4) Rapid Wien
Lokomotiva 0-2 (agg. 2-4) Genk
AEK Larnaca 0-3 (agg. 0-4) Slovan Liberec
Dinamo Tbilisi 0-2 (agg. 0-5) PAOK
Austria Wien 2-1 (agg. 4-2) Rosenborg
Beitar Jerusalem 0-0 (agg. 1-2) Saint-Etienne
Vojvodina 0-0 (agg. 0-3) AZ Alkmaar
Gabala 0-1 (agg. 3-2) Maribor
Slavia Prague 0-3 (agg. 0-6) Anderlecht
Fenerbahce 2-0 (agg. 3-0) Grasshopper
Panathinaikos 1-1 (agg. 4-1) Brondby
Krasnodar 0-0 (agg. 4-0) Partizani Tirana
Gent 4-0 (agg. 6-1) Shkendija
Istanbul Basaksehir 0-2 (agg. 1-4) Shakhtar Donetsk
SonderjyskE 2-3 (agg. 2-3) Sparta Prague
Sassuolo 1-1 (agg. 4-1) Red Star Belgrade
Goteborg 0-3 (agg. 1-3) Qarabag
Maccabi Tel Aviv 1-2 (agg. 3-3) Hajduk Split