Watch Live: Manchester United vs. Manchester City (Lineups, Stream)

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The big one has arrived.

Manchester United host Manchester City on Saturday (Watch live, 7:30 a.m. ET on NBCSN and online via NBC Sports) in a massive Manchester derby at Old Trafford.

[ STREAM: United v City live here ]

Jose Mourinho and Pep Guardiola lock horns for the first time in the Premier League after both arrived in Manchester this summer. The fierce rivals have kept things cool so far in their pre-match press conferences with Guardiola even stating he would accept a glass of wine if Mourinho offered him one after the game.

The two favorites for the Premier League title have won three from three and City have the edge on goal difference as both aim to stay perfect through Week 4. Although this game won’t be pivotal in deciding where the title will go this season, it could provide the winner, if there is one, a huge psychological boost over their crosstown rivals.

In team news Mourinho makes two changes as Jesse Lingard and Henrikh Mhkitaryan come in for Juan Mata and Anthony Martial.

Guardiola makes four changes with Kelechi Iheanacho replacing the suspended Sergio Aguero, while City also hand a debut to goalkeeper Claudio Bravo.

LINEUPS

Manchester United: De Gea; Valencia, Bailly, Blind, Shaw; Fellaini, Pogba; Lingard, Rooney, Mkhitaryan; Ibrahimovic. Subs: Mata, Martial, Smalling, Rashford, Romero, Herrera, Schneiderlin

Manchester City: Bravo; Sagna, Stones, Otamendi, Kolarov; Fernandinho, Silva; De Bruyne, Nolito, Sterling; Iheanacho. Subs: Caballero, Fernando, Zabaelta, Navas, Clichy, Garcia, Sane