The 40-game unbeaten run seems like a distant memory.
Real Madrid had lost two straight matches before a 2-1 La Liga win over Malaga on Saturday, but despite the three points, they still did lose in a way.
Los Blancos lost both Marcelo and Luka Modric to injury in the match, and both could potentially miss up to a month of time.
Modric has been in and out of the squad this season due to injuries, and during his other lengthy spell on the sidelines, he was replaced adequately by 22-year-old Mateo Kovacic, and he was the man to replace Modric against Malaga with 12 minutes remaining. Reports say the Croatian suffered an adductor injury which can be quite painful and could keep him off the field for a number of weeks.
Marcelo, meanwhile, has been a staple in the Madrid lineup, appearing in the last 11 league matches and starting all but two of those. Marcelo was brought off just 25 minutes into the Malaga win reportedly with a hamstring problem, replaced by Isco. The likely long-term replacement for the 28-year-old Brazilian would be Nacho Fernandez, who has seen time this season on both defensive flanks.
The injuries puts not just the immediate La Liga and Copa del Rey futures of the two in jeopardy, but also could affect their availability for the start of the Champions League knockout stage which begins on February 15th against Napoli.