Southampton can rise seventh with a win, while Brighton can leap into the top half with a victory as well.
Brighton and Hove Albion: Ryan; Bruno, Dunk, Duffy, Bong, Stephens, Propper, Izquierdo, Gross, Knockaert, Murray. Subs: Krul, Hemed, Goldson, March, Schelotto, Suttner, Brown.
Southampton: Forster; Cedric, Van Dijk, Hoedt, Bertrand, Davis, Romeu, Ward-Prowse, Tadic, Boufal, Gabbiadini. Subs: McCarthy, Yoshida, Stephens, Hojbjerg, McQueen, Redmond, Long.