Saints dipped into the drop zone when Stoke City won on Saturday, but will sit 14th if they can spring a home win over Spurs.
Mauricio Pellegrino is giving Mario Lemina and Manolo Gabbiadini, as well as in-form James Ward-Prowse, the starters’ chance to stop the rot. Southampton is winless in 10 league matches, but has drawn three of the last five.
Southampton: McCarthy, Cedric, Stephens, Hoedt, Bertrand, Lemina, Romeu, Ward-Prowse, Tadic, Hojbjerg, Gabbiadini. Subs: Forster, Pied, Bednarek, Davis, Boufal, Redmond, Obafemi.
Tottenham Hotspur: Vorm, Aurier, Sanchez, Vertonghen, Davies, Dier, Dembele, Sissoko, Dele, Son, Kane. Subs: Gazzaniga, Foyth, Trippier, Walker-Peters, Wanyama, Lamela, Llorente.