Top Premier League storylines — Week 27

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The Premier League’s 20 teams start their final dozen matches on Saturday, and there are plenty of interesting stories amongst the 10 weekend tilts.

[ WATCH: Coutinho’s first Barca goal ]

Can Spurs ruin their rivals’ Aubameyang honeymoon, Top Four hopes?
Tottenham Hotspur vs. Arsenal — 7:30 a.m. ET Saturday on CNBC

New look Arsenal will hope to channel some of its earlier season success in the North London Derby for a first season sweep of Spurs since 2013-14. Mauricio Pochettino‘s fifth-placed hosts enter the day with a four point advantage on the Gunners, and a loss for Arsenal would leave it a minimum of seven points back of the fourth.

Will Chelsea get form-healthy against basement-dwelling Baggies?
Chelsea vs. West Bromwich Albion — 3 p.m. ET Monday on NBCSN

What’s gone wrong at Stamford Bridge? Is Antonio Conte too intense, or perhaps some of the same players who sold out Jose Mourinho are doing the same to this title-winning boss. Chelsea needs a win to make amends for its 10-man blowout loss at Watford, and desperate West Brom won’t be sleepwalking into London.

Will Pep’s men keep their eyes off Switzerland?
Manchester City vs. Leicester City — 12:30 p.m. ET Saturday on NBC

Coming off a disappointing draw at Burnley, Man City will want to put a tricky Leicester team in its rear view mirror quickly. That won’t be easy. Leicester has beaten Man City in the Premier League during each of the previous two seasons, but can see that run end at the Etihad Stadium on Thursday

And what about Klopp’s lineup choice with Porto looming?
Southampton vs. Liverpool — 11:30 a.m. ET Sunday on NBCSN

Stung by last week’s draw with Spurs, Liverpool now has to refocus for a trip to St. Mary’s (the old haunt for so many of those players). Will Jurgen Klopp use Virgil Van Dijk on return, with a UEFA Champions League trip to Portugal next week? Saints, meanwhile, will aim to move further clear of the drop zone. Southampton enters the day two points out of 18th.

And the relegation six-pointer of the weekend is…
Stoke City vs. Brighton and Hove Albion — 10 a.m. ET Saturday on CNBC

Chris Hughton‘s Gulls are three points clear of the 18th place spot occupied by… Stoke City. Few expected the Potters to be flirting with the drop zone this deep into the season, and Paul Lambert will hope to get more than just good bounces from Brighton’s visit.