Chelsea and Leicester City were the first clubs to progress into the FA Cup quarterfinals, so which sides will join them on Saturday?
[ MORE: Willian stars for Chelsea, as the Blues move into the sixth round ]
Six Premier League clubs will be in action, including Manchester United, who takes on fellow top-flight cohorts Huddersfield Town at the Kirklees Stadium.
[ LIVE: Follow all the FA Cup scores ]
Meanwhile, Sheffield Wednesday and Coventry City each aim to continue their impressive runs in this season’s competition, as they take on Swansea City and Brighton & Hove Albion, respectively.
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Below is the full schedule for Saturday’s FA Cup matches.
Sheffield Wednesday vs. Swansea City — 7:30 a.m. ET
Brighton & Hove Albion vs. Coventry City — 10 a.m. ET
West Bromwich Albion vs. Southampton — 10 a.m. ET
Huddersfield Town vs. Manchester United — 12:30 p.m. ET