Southampton can climb out of the relegation zone with a surprising win over Arsenal at the Emirates Stadium on Sunday (Watch live at 9:15 a.m. ET on NBCSN and online via NBCSports.com).
Arsenal is three days removed from a 4-1 home win over CSKA Moscow, and has the second leg Thursday in Russia before meeting Newcastle United in league play.
The Gunners open the day five points back of fifth-place Chelsea, who stages a London Derby against West Ham United later Sunday.
Saints are three behind Crystal Palace and have played two fewer matches.
Arsenal: Cech; Bellerin, Chambers, Mustafi, Kolasinac, Elneny, Xhaka, Iwobi, Nelson, Welbeck, Aubameyang. Subs: Macey, Holding, Monreal, Wilshere, Ozil, Lacazette, Nketiah
Southampton: McCarthy; Cedric, Stephens, Hoedt, Yoshida, Bertrand, Romeu, Tadic, Hojbjerg, Ward-Prowse, Long. Subs: Forster, Pied, Redmond, Sims, Boufal, Austin, Gabbiadini.