Major League Soccer enters the fray as the Lamar Hunt U.S. Open Cup reaches its fourth round.
There are four all-MLS matches in the bunch, including another round of the Hudson River Derby between NYCFC and the New York Red Bulls.
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Elsewhere, Portland hosts San Jose, Chicago visits Columbus, and Real Salt Lake entertains Sporting KC.
Open qualifier NTX Rayados earn a date at Houston Dynamo, while PDL side FC Golden State Force will visit the LA Galaxy.
NPSL side Miami United hosts Orlando City as an MLS side travels to visit a fourth-tier side.
The rest of the match-ups feature USL sides vs. MLS teams.
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The winner of the U.S. Open Cup gets a spot in the CONCACAF Champions League.
Full schedule (June 5-6)
New York Red Bulls vs. NYCFC
Louisville City (USL) vs. New England Revolution
DC United vs. North Carolina FC (USL)
Philadelphia Union vs. Richmond Kickers (USL)
Miami United (NPSL) vs. Orlando City SC
Atlanta United vs. Charleston Battery (USL)
Minnesota United vs. FC Cincinnati (USL)
Columbus Crew vs. Chicago Fire
Nashville SC (USL) vs. Colorado Rapids
Real Salt Lake vs. Sporting KC
Houston Dynamo vs. NTX Rayados (LQ)
San Antonio FC (USL) vs. FC Dallas
LA Galaxy vs. FC Golden State Force (PDL)
LAFC vs. Fresno FC (USL)
Portland Timbers vs. San Jose Earthquakes
Sacramento Republic (USL) vs. Seattle Sounders