Arsenal is in Azerbaijan without Henrikh Mkhitaryan, while Chelsea hosts Hungarian opposition as the 2018-19 Europa League group stage moves into its second match day.
One match began earlier, with Astana and Stade Rennes matching wits in Kazakhstan.
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Unai Emery is keeping several big names out of the fire, or at least the Starting XI, at Qarabag for a 12:55 p.m. ET ahead of the Sunday’s Premier League match at Fulham.
In addition to Mkhitaryan staying home for political reasons, Pierre-Emerick Aubameyang (rest) and Aaron Ramsey (wife giving birth) are back in London, while Alexandre Lacazette and Mesut Ozil are on the bench.
Chelsea hosts MOL Vidi at 3 p.m. ET