A minimum of one lower league side will feature in the Lamar Hunt U.S. Open Cup’s Round of 16.
New Mexico United got a helping hand from a red card, defeating Colorado Rapids in dramatic fashion on Wednesday night.
[ MORE: Premier League schedule announced ]
Devon Sandoval gave the USL visitors a stunning lead, but Diego Rubio and Nicolas Mezquida scored on either side of halftime to restore order to the MLS hosts.
Then Axel Sjoberg was shown a 72nd minute red card, and Kevaughn Frater pushed an equalizer over the line deep into stoppage time to set up penalty kicks.
A second team could join New Mexico, but that would require a surprising win by Charleston Battery on Thursday versus Atlanta United.
A non-MLS club has won the USOC since the Rochester Rhinos in 1999.
Round of 16 schedule
Columbus Crew v. Atlanta United/Charleston Battery (USL)
Saint Louis FC v. FC Cincinnati
Orlando City v. New England Revolution
DC United v. NYCFC
LAFC v. San Jose Earthquakes
Portland Timbers v. LA Galaxy
Houston Dynamo v. Minnesota United
FC Dallas v. New Mexico United (USL)