Alisson Becker was the hero in penalty kicks after hosts Brazil failed to break down 10-man Paraguay at the Copa America on Thursday.
Paraguay eliminated Brazil from the 2011 and 2015 editions of the tournament in penalty kicks.
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Brazil outshot Paraguay 26-5, and will face the winners of Argentina and Venezuela in the semifinals.
Gatito Fernandez made 13 saves in the loss.
Fabian Balbuena’s 58th minute red card complicated the matter for Paraguay, but the underdogs held out for kicks.
Alisson saved the first penalty of the round, and Willian gave Brazil its advantage.
Roberto Firmino slapped a right-footed shot wide, but Derlis Gonzalez did the same and Brazil held on for a semifinal spot.