A half-hour of the big guns wasn’t enough to get Jurgen Klopp a result against his former team.
Paco Alcacer, Thomas Delaney, and Jacob Bruun Larsen scored for the Black Yellow, who led 3-1 when mass changes began with Virgil Van Dijk, Georginio Wijnaldum, Trent Alexander-Arnold, Jordan Henderson, and Andrew Robertson entering the match.
Liverpool faces Sevilla on Sunday at Fenway Park in Boston.
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Wilson leveled the score before halftime, but Delaney made it 2-1 in the 53rd minute when a long diagonal ball beat the Reds line and a low pass across the box went undetected.