Hazard had only returned to the lineup for two matches following a three-month absence with an ankle injury.
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The 29-year-old has made just 15 appearances for Real since arriving in a big-money move from Chelsea, scoring once with five assists.
He has never appeared in less than 30 league matches over the course of his career, five times missing one or zero matches.
Of course, all of his absences show that Real is very comfortable playing and winning without Hazard. Zinedine Zidane’s men lost Sunday to drop behind Barcelona in La Liga, but that was just its second loss of the league season.
Real will be taxed in depth like its rivals, with Wednesday’s visit from Man City followed by an El Clasico at the Bernabeu on March 1. Barcelona hosts Napoli on Tuesday.
Whether you like the playmaker or despise him, there must be some sense of sympathy for his latest ailments (even if Man City and Barca fans will likely offer a Jerry Seinfeld-esque, “That’s a shame”).