Ryan Mason, 29, has been placed in interim charge until the end of the season, and Tottenham still have a chance of finishing in the top four and have the League Cup final at Wembley against Manchester City on Sunday.
Since their 2-2 draw at Everton last Friday, Mourinho has been fired and Daniel Levy has signed Spurs up to the hugely-contentious European Super League as fans will no doubt protest outside their stadium before this clash.
As for Southampton, well, they continue to struggle and they lost their FA Cup semifinal to Leicester City at Wembley on Sunday as Ralph Hasenhuttl’s men are now fully-focused on trying to push for a top 10 finish late in the season.
Here’s everything you need to know ahead of Tottenham – Southampton, as Spurs have to win to keep their faint hopes of finishing in the top four alive.
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Tottenham will not have Harry Kane available through injury, as he damaged his ankle on Friday and Mason revealed he is a doubt to play in the League Cup final on Sunday. Matt Doherty is back in training, while Ben Davies is out.
— Tottenham Hotspur (@SpursOfficial) April 21, 2021
Southampton have long-term absentees Will Smallbone and Oriol Romeu missing, while Michael Obafemi is back in training.
🚨 T E A M S H E E T 🚨
— Southampton FC (@SouthamptonFC) April 21, 2021
Odds and ends (full odds provided by our partner, PointsBet)
Tottenham are the heavy favorites at -125, while Southampton are +325 to cause a shock. The draw is +265.
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This is a tough one to call, but you would think we will see some kind of reaction from Spurs after Mourinho was fired. They hammered Saints, especially on the counter, earlier this season and Southampton are extremely low on confidence. Go for a narrow Spurs win, but they have more than one eye on the League Cup final this weekend. Tottenham 2-1 Southampton.
How to watch, stream and start time
Kick off: 1pm ET, Wednesday
TV Channel and Online: Peacock Premium